BDBM50221697 1,3-dimethyl-9-phenethyl-6,7,8,9-tetrahydropyrimido[1,2-a]purine-2,4(1H,3H)-dione::CHEMBL239864

SMILES Cn1c2nc3N(CCc4ccccc4)CCCn3c2c(=O)n(C)c1=O

InChI Key InChIKey=PPHQNKPUIYRVIK-UHFFFAOYSA-N

Data  6 KI  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50221697   

TargetN-arachidonyl glycine receptor(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50221697(1,3-dimethyl-9-phenethyl-6,7,8,9-tetrahydropyrimid...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetN-arachidonyl glycine receptor(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50221697(1,3-dimethyl-9-phenethyl-6,7,8,9-tetrahydropyrimid...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as inhibition of THC-induced beta arrestin recruitment af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetG-protein coupled receptor 55(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50221697(1,3-dimethyl-9-phenethyl-6,7,8,9-tetrahydropyrimid...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at Prolink1-tagged human GPR55 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetG-protein coupled receptor 55(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50221697(1,3-dimethyl-9-phenethyl-6,7,8,9-tetrahydropyrimid...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at Prolink1-tagged human GPR55 receptor expressed in CHO cells assessed as inhibition of lysophosphatidylinositol-induced beta ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50221697(1,3-dimethyl-9-phenethyl-6,7,8,9-tetrahydropyrimid...)
Affinity DataKi:  320nMAssay Description:Displacement of [3H]MSX2 from adenosine A2A receptor in rat brain striatal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50221697(1,3-dimethyl-9-phenethyl-6,7,8,9-tetrahydropyrimid...)
Affinity DataKi:  2.89E+3nMAssay Description:Displacement of [3H]MSX2 from human adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50221697(1,3-dimethyl-9-phenethyl-6,7,8,9-tetrahydropyrimid...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]PSB11 from human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50221697(1,3-dimethyl-9-phenethyl-6,7,8,9-tetrahydropyrimid...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50221697(1,3-dimethyl-9-phenethyl-6,7,8,9-tetrahydropyrimid...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50221697(1,3-dimethyl-9-phenethyl-6,7,8,9-tetrahydropyrimid...)
Affinity DataKi: >2.50E+4nMAssay Description:Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed