BDBM50221670 CHEMBL241212::N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-4-ethynylbenzamide

SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(cc2)C#C)CC1

InChI Key InChIKey=CQLNLMLQKSNCPW-UHFFFAOYSA-N

Data  4 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50221670   

TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50221670(N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-4-e...)
Affinity DataEC50:  2.10nMAssay Description:Agonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50221670(N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-4-e...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]spiperone from human cloned dopamine D3 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50221670(N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-4-e...)
Affinity DataKi:  160nMAssay Description:Displacement of [3H]spiperone from human cloned dopamine receptor D2 short expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50221670(N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-4-e...)
Affinity DataKi:  250nMAssay Description:Displacement of [3H]spiperone from human cloned dopamine receptor D2 long expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Pig)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50221670(N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-4-e...)
Affinity DataKi:  3.00E+3nMAssay Description:Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed