BDBM50221556 4-chloro-3-(5-methyl-3-(4-(piperidin-4-ylsulfonyl)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenol::7-(2-chloro-5-hydroxyphenyl)-5-methyl-N-[4-(piperidin-4-ylsulfonyl)phenyl]-1,2,4-benzotriazin-3-amine::CHEMBL250625::US8481536, 536::US8481536, 617

SMILES Cc1cc(cc2nnc(Nc3ccc(cc3)S(=O)(=O)C3CCNCC3)nc12)-c1cc(O)ccc1Cl

InChI Key InChIKey=VAWLAPYBUJTXRS-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50221556   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

US Patent
LigandPNGBDBM50221556(US8481536, 617 | 4-chloro-3-(5-methyl-3-(4-(piperi...)
Affinity DataIC50: 5.20nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Targegen

US Patent
LigandPNGBDBM50221556(US8481536, 617 | 4-chloro-3-(5-methyl-3-(4-(piperi...)
Affinity DataIC50: 2.80nMAssay Description:Pdgfrβ (0.16 ug/well, Panvera/Invitrogen) 500 nM ATP and the PTK2 peptide (700 uM) were combined with compound and reaction buffer as noted abov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

US Patent
LigandPNGBDBM50221556(US8481536, 617 | 4-chloro-3-(5-methyl-3-(4-(piperi...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50221556(US8481536, 617 | 4-chloro-3-(5-methyl-3-(4-(piperi...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50221556(US8481536, 617 | 4-chloro-3-(5-methyl-3-(4-(piperi...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of YESMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50221556(US8481536, 617 | 4-chloro-3-(5-methyl-3-(4-(piperi...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed