BDBM50221555 4-chloro-3-(5-methyl-3-(4-(3-(pyrrolidin-1-yl)propylsulfonyl)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenol::CHEMBL399268::US8481536, 511::US8481536, 613

SMILES Cc1cc(cc2nnc(Nc3ccc(cc3)S(=O)(=O)CCCN3CCCC3)nc12)-c1cc(O)ccc1Cl

InChI Key InChIKey=RCZHVXSTTOXWRM-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50221555   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

US Patent
LigandPNGBDBM50221555(CHEMBL399268 | US8481536, 511 | US8481536, 613 | 4...)
Affinity DataIC50: 5nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
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TargetPlatelet-derived growth factor receptor beta(Human)
Targegen

US Patent
LigandPNGBDBM50221555(CHEMBL399268 | US8481536, 511 | US8481536, 613 | 4...)
Affinity DataIC50: 2.90nMAssay Description:Pdgfrβ (0.16 ug/well, Panvera/Invitrogen) 500 nM ATP and the PTK2 peptide (700 uM) were combined with compound and reaction buffer as noted abov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ABL1(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50221555(CHEMBL399268 | US8481536, 511 | US8481536, 613 | 4...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed