BDBM50221529 7-(4-(morpholinomethyl)phenyl)-4-((1R,2S)-2-phenylcyclopropylamino)quinoline-3-carbonitrile::CHEMBL399438

SMILES N#Cc1cnc2cc(ccc2c1N[C@@H]1C[C@H]1c1ccccc1)-c1ccc(CN2CCOCC2)cc1

InChI Key InChIKey=VIGFESXSWDXMJU-UHFFFAOYSA-N

Data  6 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50221529   

TargetEpidermal growth factor receptor(Human)
Tanabe Research Laboratories Usa

Curated by ChEMBL
LigandPNGBDBM50221529(7-(4-(morpholinomethyl)phenyl)-4-((1R,2S)-2-phenyl...)
Affinity DataIC50: 234nMAssay Description:Inhibition of human EGFR autophosphorylation in A431 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Tanabe Research Laboratories Usa

Curated by ChEMBL
LigandPNGBDBM50221529(7-(4-(morpholinomethyl)phenyl)-4-((1R,2S)-2-phenyl...)
Affinity DataKi:  80nMAssay Description:Inhibition of human recombinant EGFR by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Tanabe Research Laboratories Usa

Curated by ChEMBL
LigandPNGBDBM50221529(7-(4-(morpholinomethyl)phenyl)-4-((1R,2S)-2-phenyl...)
Affinity DataKi:  140nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tanabe Research Laboratories Usa

Curated by ChEMBL
LigandPNGBDBM50221529(7-(4-(morpholinomethyl)phenyl)-4-((1R,2S)-2-phenyl...)
Affinity DataKi:  170nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Tanabe Research Laboratories Usa

Curated by ChEMBL
LigandPNGBDBM50221529(7-(4-(morpholinomethyl)phenyl)-4-((1R,2S)-2-phenyl...)
Affinity DataKi:  300nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Tanabe Research Laboratories Usa

Curated by ChEMBL
LigandPNGBDBM50221529(7-(4-(morpholinomethyl)phenyl)-4-((1R,2S)-2-phenyl...)
Affinity DataKi:  300nMAssay Description:Inhibition of ABLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Tanabe Research Laboratories Usa

Curated by ChEMBL
LigandPNGBDBM50221529(7-(4-(morpholinomethyl)phenyl)-4-((1R,2S)-2-phenyl...)
Affinity DataKi:  920nMAssay Description:Inhibition of Flt1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed