BDBM50221153 (R)-8a-(4-methoxybenzyl)-2-(4-tert-butylphenylsulfonyl)-1,2,3,4,8,8a-hexahydroisoquinolin-6(7H)-one::CHEMBL250700

SMILES COc1ccc(C[C@]23CCC(=O)C=C2CCN(C3)S(=O)(=O)c2ccc(cc2)C(C)(C)C)cc1

InChI Key InChIKey=SORRVACNJJPKKG-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50221153   

TargetGlucocorticoid receptor(Human)
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50221153((R)-8a-(4-methoxybenzyl)-2-(4-tert-butylphenylsulf...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50221153((R)-8a-(4-methoxybenzyl)-2-(4-tert-butylphenylsulf...)
Affinity DataKi:  200nMAssay Description:Antagonist activity at human glucocorticoid receptor in SW1353 cells assessed as inhibition of dexamethasone-induced luciferase expression by MMTV5 r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50221153((R)-8a-(4-methoxybenzyl)-2-(4-tert-butylphenylsulf...)
Affinity DataKi:  352nMAssay Description:Binding affinity to glucocorticoid receptor in SW1353 cells by whole-cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed