BDBM50220232 (S)-benzyl 4-(5-((2-aminophenyl)carbamoyl)pyridin-2-yl)-2-methylpiperazine-1-carboxylate::(S)-benzyl 4-(5-(2-aminophenylcarbamoyl)pyridin-2-yl)-2-methylpiperazine-1-carboxylate::CHEMBL236902

SMILES C[C@H]1CN(CCN1C(=O)OCc1ccccc1)c1ccc(cn1)C(=O)Nc1ccccc1N

InChI Key InChIKey=UQKHQHYWAJFGDY-UHFFFAOYSA-N

Data  1 KI  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50220232   

TargetSodium-dependent dopamine transporter(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220232((S)-benzyl 4-(5-(2-aminophenylcarbamoyl)pyridin-2-...)
Affinity DataIC50: 3.12E+3nMAssay Description:Activity against human dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220232((S)-benzyl 4-(5-(2-aminophenylcarbamoyl)pyridin-2-...)
Affinity DataIC50: 73nMAssay Description:Inhibition of recombinant HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220232((S)-benzyl 4-(5-(2-aminophenylcarbamoyl)pyridin-2-...)
Affinity DataIC50: 1.67E+4nMAssay Description:Inhibition of recombinant HDAC8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220232((S)-benzyl 4-(5-(2-aminophenylcarbamoyl)pyridin-2-...)
Affinity DataIC50: 4.52E+3nMAssay Description:Activity against human MAPK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220232((S)-benzyl 4-(5-(2-aminophenylcarbamoyl)pyridin-2-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220232((S)-benzyl 4-(5-(2-aminophenylcarbamoyl)pyridin-2-...)
Affinity DataIC50: 1.68E+3nMAssay Description:Activity against human serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220232((S)-benzyl 4-(5-(2-aminophenylcarbamoyl)pyridin-2-...)
Affinity DataIC50: 939nMAssay Description:Inhibition of recombinant HDAC3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220232((S)-benzyl 4-(5-(2-aminophenylcarbamoyl)pyridin-2-...)
Affinity DataIC50: 272nMAssay Description:Inhibition of recombinant HDAC2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220232((S)-benzyl 4-(5-(2-aminophenylcarbamoyl)pyridin-2-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220232((S)-benzyl 4-(5-(2-aminophenylcarbamoyl)pyridin-2-...)
Affinity DataIC50: 2.45E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220232((S)-benzyl 4-(5-(2-aminophenylcarbamoyl)pyridin-2-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant HDAC6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220232((S)-benzyl 4-(5-(2-aminophenylcarbamoyl)pyridin-2-...)
Affinity DataIC50: 79nMAssay Description:Inhibition of human HDAC1 expressed in mammalian cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220232((S)-benzyl 4-(5-(2-aminophenylcarbamoyl)pyridin-2-...)
Affinity DataIC50: 308nMAssay Description:Inhibition of human HDAC2 expressed in mammalian cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220232((S)-benzyl 4-(5-(2-aminophenylcarbamoyl)pyridin-2-...)
Affinity DataIC50: 942nMAssay Description:Inhibition of human HDAC3 expressed in mammalian cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220232((S)-benzyl 4-(5-(2-aminophenylcarbamoyl)pyridin-2-...)
Affinity DataKi: >3.00E+4nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed