BDBM50219114 CHEMBL244773::N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-trans-but-2-enyl)-4-(3-methylpyridin-2-yl)benzamide::US8748608, 11

SMILES Cc1cccnc1-c1ccc(cc1)C(=O)NC\C=C\CN1CCN(CC1)c1cccc(Cl)c1Cl

InChI Key InChIKey=MTJYJBYKMIGLMS-UHFFFAOYSA-N

Data  6 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50219114   

TargetD(2) dopamine receptor(Human)
The United States of America As Represented By The Secretary of The Department of Health and Human Services

US Patent
LigandPNGBDBM50219114(US8748608, 11 | CHEMBL244773 | N-(4-(4-(2,3-dichlo...)
Affinity DataIC50: 368nMT: 2°CAssay Description:To measure D2 and D3 stimulation of mitogenesis (agonist assay) or D2 and D3 inhibition of quinpirole stimulation of mitogenesis (antagonist assay), ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2014
Entry Details
Go to US Patent

TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219114(US8748608, 11 | CHEMBL244773 | N-(4-(4-(2,3-dichlo...)
Affinity DataIC50: 25.6nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
The United States of America As Represented By The Secretary of The Department of Health and Human Services

US Patent
LigandPNGBDBM50219114(US8748608, 11 | CHEMBL244773 | N-(4-(4-(2,3-dichlo...)
Affinity DataIC50: 368nMAssay Description:Antagonist activity at human dopamine D2 receptor expressed in HEK293 cells by mitogenesis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219114(US8748608, 11 | CHEMBL244773 | N-(4-(4-(2,3-dichlo...)
Affinity DataKi:  1.60nM IC50: 25.6nMAssay Description:Methods for performing in vitro dopamine receptor binding studies are described in Huang et al. J. Med. Chem. 44:1815-1826 (2001) and Luedtke et al. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2014
Entry Details
Go to US Patent

TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219114(US8748608, 11 | CHEMBL244773 | N-(4-(4-(2,3-dichlo...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [125I]IABN from human dopamine D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219114(US8748608, 11 | CHEMBL244773 | N-(4-(4-(2,3-dichlo...)
Affinity DataKi:  31nMAssay Description:Binding affinity to human 5HT2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219114(US8748608, 11 | CHEMBL244773 | N-(4-(4-(2,3-dichlo...)
Affinity DataKi:  46.9nMAssay Description:Binding affinity to human 5HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219114(US8748608, 11 | CHEMBL244773 | N-(4-(4-(2,3-dichlo...)
Affinity DataKi:  92nMAssay Description:Binding affinity to human 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
The United States of America As Represented By The Secretary of The Department of Health and Human Services

US Patent
LigandPNGBDBM50219114(US8748608, 11 | CHEMBL244773 | N-(4-(4-(2,3-dichlo...)
Affinity DataKi:  92nMAssay Description:Displacement of [125I]IABN from human dopamine D2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed