BDBM50219113 CHEMBL244989::N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)-trans-but-2-enyl)-9H-fluorene-2-carboxamide::US8748608, 15

SMILES COc1ccccc1N1CCN(C\C=C\CNC(=O)c2ccc-3c(Cc4ccccc-34)c2)CC1

InChI Key InChIKey=UUYDEYACQFNFMI-UHFFFAOYSA-N

Data  6 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50219113   

TargetD(2) dopamine receptor(Human)
The United States of America As Represented By The Secretary of The Department of Health and Human Services

US Patent
LigandPNGBDBM50219113(US8748608, 15 | CHEMBL244989 | N-(4-(4-(2-methoxyp...)
Affinity DataIC50: 179nMT: 2°CAssay Description:To measure D2 and D3 stimulation of mitogenesis (agonist assay) or D2 and D3 inhibition of quinpirole stimulation of mitogenesis (antagonist assay), ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2014
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
The United States of America As Represented By The Secretary of The Department of Health and Human Services

US Patent
LigandPNGBDBM50219113(US8748608, 15 | CHEMBL244989 | N-(4-(4-(2-methoxyp...)
Affinity DataIC50: 179nMAssay Description:Antagonist activity at human dopamine D2 receptor expressed in HEK293 cells by mitogenesis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219113(US8748608, 15 | CHEMBL244989 | N-(4-(4-(2-methoxyp...)
Affinity DataIC50: 18.9nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219113(US8748608, 15 | CHEMBL244989 | N-(4-(4-(2-methoxyp...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [125I]IABN from human dopamine D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219113(US8748608, 15 | CHEMBL244989 | N-(4-(4-(2-methoxyp...)
Affinity DataKi:  12nM IC50: 18.9nMAssay Description:Methods for performing in vitro dopamine receptor binding studies are described in Huang et al. J. Med. Chem. 44:1815-1826 (2001) and Luedtke et al. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2014
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
The United States of America As Represented By The Secretary of The Department of Health and Human Services

US Patent
LigandPNGBDBM50219113(US8748608, 15 | CHEMBL244989 | N-(4-(4-(2-methoxyp...)
Affinity DataKi:  48.4nMAssay Description:Displacement of [125I]IABN from human dopamine D2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219113(US8748608, 15 | CHEMBL244989 | N-(4-(4-(2-methoxyp...)
Affinity DataKi:  65.7nMAssay Description:Binding affinity to human 5HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219113(US8748608, 15 | CHEMBL244989 | N-(4-(4-(2-methoxyp...)
Affinity DataKi:  71.8nMAssay Description:Binding affinity to human 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219113(US8748608, 15 | CHEMBL244989 | N-(4-(4-(2-methoxyp...)
Affinity DataKi:  176nMAssay Description:Binding affinity to human 5HT2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed