BDBM50219049 1-(4-Chloro-phenyl)-4-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-butan-1-one::1-(4-chlorophenyl)-4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)butan-1-one::CHEMBL363548

SMILES OC1(CCN(CCCC(=O)c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1

InChI Key InChIKey=QETRGFJTEVVJTC-UHFFFAOYSA-N

Data  5 KI  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50219049   

TargetD(2) dopamine receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50219049(1-(4-chlorophenyl)-4-(4-(4-chlorophenyl)-4-hydroxy...)
Affinity DataKd:  5nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50219049(1-(4-chlorophenyl)-4-(4-(4-chlorophenyl)-4-hydroxy...)
Affinity DataKd:  5nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetN-acetyltransferase Eis(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50219049(1-(4-chlorophenyl)-4-(4-(4-chlorophenyl)-4-hydroxy...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis Eis assessed as Eis-mediated kanamycin acetylation preincubated for 10 mins followed by substrate addition a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50219049(1-(4-chlorophenyl)-4-(4-(4-chlorophenyl)-4-hydroxy...)
Affinity DataKi:  5nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50219049(1-(4-chlorophenyl)-4-(4-(4-chlorophenyl)-4-hydroxy...)
Affinity DataKi:  5nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50219049(1-(4-chlorophenyl)-4-(4-(4-chlorophenyl)-4-hydroxy...)
Affinity DataKi:  150nMAssay Description:Displacement of [125I]HEAT from human recombinant adrenergic alpha-1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50219049(1-(4-chlorophenyl)-4-(4-(4-chlorophenyl)-4-hydroxy...)
Affinity DataKi:  190nMAssay Description:Displacement of [3H]spiperone from human recombinant dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Rat)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50219049(1-(4-chlorophenyl)-4-(4-(4-chlorophenyl)-4-hydroxy...)
Affinity DataKi:  350nMAssay Description:Displacement of [3H]T-226296 from rat recombinant MCH1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed