BDBM50218464 (Z)-4-(5,7,7,10,10-pentamethyl-2-nitro-7,8,9,10-tetrahydro-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)benzoic acid::4-(5,7,7,10,10-pentamethyl-2-nitro-7,8,9,10-tetrahydro-5H-5,13-diaza-benzo[4,5]cyclohepta[1,2-b]naphthalen-12-yl)-benzoic acid::CHEMBL326525

SMILES CN1c2ccc(cc2N=C(c2ccc(cc2)C(O)=O)c2cc3c(cc12)C(C)(C)CCC3(C)C)[N+]([O-])=O

InChI Key InChIKey=SXKPGYKPQPYJER-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50218464   

TargetRetinoic acid receptor RXR-alpha(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50218464(4-(5,7,7,10,10-pentamethyl-2-nitro-7,8,9,10-tetrah...)
Affinity DataIC50: 1.20E+3nMAssay Description:Antagonist activity at human RXRalpha expressed in EK293 cells assessed as inhibition of LG-100268-induced transactivationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50218464(4-(5,7,7,10,10-pentamethyl-2-nitro-7,8,9,10-tetrah...)
Affinity DataIC50: 900nMAssay Description:Antagonist activity at human RXRalpha expressed in EK293 cells assessed as inhibition of 9-cis-retinoic acid-induced transactivationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-beta(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50218464(4-(5,7,7,10,10-pentamethyl-2-nitro-7,8,9,10-tetrah...)
Affinity DataIC50: 44nMAssay Description:Antagonist activity at RXRbeta expressed in african green monkey COS1 cells assessed as inhibition of LGD-1069-induced agonist activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50218464(4-(5,7,7,10,10-pentamethyl-2-nitro-7,8,9,10-tetrah...)
Affinity DataIC50: 290nMAssay Description:Antagonist activity at RXRalpha expressed in african green monkey COS1 cells assessed as inhibition of LGD-1069-induced agonist activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-gamma(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50218464(4-(5,7,7,10,10-pentamethyl-2-nitro-7,8,9,10-tetrah...)
Affinity DataIC50: 380nMAssay Description:Antagonist activity at RXRgamma expressed in african green monkey COS1 cells assessed as inhibition of LGD-1069-induced agonist activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50218464(4-(5,7,7,10,10-pentamethyl-2-nitro-7,8,9,10-tetrah...)
Affinity DataEC50:  1.00E+3nMAssay Description:Antagonist activity at RXRalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed