BDBM50217191 CHEMBL248108::N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-5-((4-aminopiperidin-1-yl)methyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine

SMILES NC1CCN(Cc2ccn3ncnc(Nc4ccc5n(Cc6cccc(F)c6)ncc5c4)c23)CC1

InChI Key InChIKey=WDJUUISIVREQHL-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50217191   

TargetHepatocyte growth factor receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217191(N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-5-((4-amino...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of MetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217191(N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-5-((4-amino...)
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant EGFR expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217191(N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-5-((4-amino...)
Affinity DataIC50: 710nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217191(N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-5-((4-amino...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217191(N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-5-((4-amino...)
Affinity DataIC50: 480nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217191(N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-5-((4-amino...)
Affinity DataIC50: 23nMAssay Description:Inhibition of human recombinant HER2 expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217191(N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-5-((4-amino...)
Affinity DataIC50: 35nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217191(N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-5-((4-amino...)
Affinity DataIC50: 22nMAssay Description:Inhibition of HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed