BDBM50216786 CHEMBL229457::N-(7-Amino-heptyl)-guanidine::N-guanyl-1,7-diaminoheptane

SMILES [#7]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7]

InChI Key InChIKey=WQFCOYDHLNYCIG-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50216786   

TargetDeoxyhypusine synthase(Rat)
National Institute of Dental Research

Curated by ChEMBL
LigandPNGBDBM50216786(N-(7-Amino-heptyl)-guanidine | N-guanyl-1,7-diamin...)
Affinity DataIC50: 30nMAssay Description:In vitro IC50 value by measuring the inhibition of deoxyhypusine synthase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDeoxyhypusine synthase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50216786(N-(7-Amino-heptyl)-guanidine | N-guanyl-1,7-diamin...)
Affinity DataIC50: 140nMAssay Description:Inhibition of human N-terminal His6-tagged TEV protease site linked DHPS expressed in Escherichia coli BL21 (DE3) assessed as reduction in radiolabel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetDeoxyhypusine synthase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50216786(N-(7-Amino-heptyl)-guanidine | N-guanyl-1,7-diamin...)
Affinity DataIC50: 500nMAssay Description:Competitive inhibition of human N-terminal His6-tagged TEV protease site linked DHPS expressed in Escherichia coli BL21 (DE3) assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetDeoxyhypusine synthase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50216786(N-(7-Amino-heptyl)-guanidine | N-guanyl-1,7-diamin...)
Affinity DataIC50: 1.72E+3nMAssay Description:Inhibition of DHPS (unknown origin ) incubated for 30 mins by NAD/NADH-Glow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetDeoxyhypusine synthase(malaria parasite P. falciparum)
Institute For Medical Parasitology

Curated by ChEMBL
LigandPNGBDBM50216786(N-(7-Amino-heptyl)-guanidine | N-guanyl-1,7-diamin...)
Affinity DataKi:  100nMAssay Description:Inhibition of recombinant deoxyhypusine synthase in Plasmodium falciparum NF54More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed