BDBM50216419 2-{1-(4-methoxy-benzyl)-2-oxo-5-[2-(pyridin-3-yloxymethyl)-pyrrolidine-1-sulfonyl]-1,2-dihydro-indol-3-yl-idene}-malononitrile::CHEMBL427284

SMILES [#6]-[#8]-c1ccc(-[#6]-[#7]-2-[#6](=O)\[#6](=[#6](\C#N)C#N)-c3cc(ccc-23)S(=O)(=O)[#7]-2-[#6]-[#6]-[#6]-[#6@H]-2-[#6]-[#8]-c2cccnc2)cc1

InChI Key InChIKey=RYFOPZVXCSEZKO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50216419   

TargetCaspase-1(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50216419(2-{1-(4-methoxy-benzyl)-2-oxo-5-[2-(pyridin-3-ylox...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of human recombinant caspase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50216419(2-{1-(4-methoxy-benzyl)-2-oxo-5-[2-(pyridin-3-ylox...)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-6(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50216419(2-{1-(4-methoxy-benzyl)-2-oxo-5-[2-(pyridin-3-ylox...)
Affinity DataIC50: 610nMAssay Description:Inhibition of human recombinant caspase 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-7(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50216419(2-{1-(4-methoxy-benzyl)-2-oxo-5-[2-(pyridin-3-ylox...)
Affinity DataIC50: 29.6nMAssay Description:Inhibition of human recombinant caspase 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-8(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50216419(2-{1-(4-methoxy-benzyl)-2-oxo-5-[2-(pyridin-3-ylox...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant caspase 8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed