BDBM50216333 CHEBI:67357::DOLASTATIN-10::Dolastatin 10::Dolostatin 10

SMILES CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](Cc2ccccc2)c3nccs3)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)C

InChI Key InChIKey=OFDNQWIFNXBECV-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50216333   

TargetTubulin alpha-1A chain(Pig)
Laboratoire Des M£Canismes Mol£Culaires Des Communications Cellulaires (Cnrs Upr 9023)

Curated by ChEMBL
LigandPNGBDBM50216333(DOLASTATIN-10 | CHEBI:67357 | Dolastatin 10 | Dolo...)
Affinity DataIC50: 2.20E+3nMAssay Description:Compound was tested in vitro for inhibition of tubulin polymerization.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Upr 9023 Cnrs

Curated by ChEMBL
LigandPNGBDBM50216333(DOLASTATIN-10 | CHEBI:67357 | Dolastatin 10 | Dolo...)
Affinity DataIC50: 2.20E+3nMAssay Description:In vitro inhibition of tubulin polymerization measured as turbidity formed by centrifugationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed