BDBM50216046 2-(4-(4-phenyl-1-piperazinyl)butyl)-1,2-benzisothiazole-3(2H)-one 1,1-dioxide::CHEMBL238917

SMILES COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1

InChI Key InChIKey=QMIUZKMFRCDUKI-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50216046   

TargetD(2) dopamine receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50216046(2-(4-(4-phenyl-1-piperazinyl)butyl)-1,2-benzisothi...)
Affinity DataKi:  6.20nMAssay Description:Antagonist activity at human Dopamine receptor D2 isoform long expressed in HEK293 cells assessed as change in quinpirole-induced intracellular calci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Cracow University of Technology

Curated by ChEMBL
LigandPNGBDBM50216046(2-(4-(4-phenyl-1-piperazinyl)butyl)-1,2-benzisothi...)
Affinity DataKi:  79nMAssay Description:Binding affinity to human D4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50216046(2-(4-(4-phenyl-1-piperazinyl)butyl)-1,2-benzisothi...)
Affinity DataKi:  187nMAssay Description:Displacement of [3H]spiperone from human Dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Cracow University of Technology

Curated by ChEMBL
LigandPNGBDBM50216046(2-(4-(4-phenyl-1-piperazinyl)butyl)-1,2-benzisothi...)
Affinity DataKi:  187nMAssay Description:Binding affinity to human D3RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50216046(2-(4-(4-phenyl-1-piperazinyl)butyl)-1,2-benzisothi...)
Affinity DataKi:  360nMAssay Description:Displacement of [3H]Spiperone from human Dopamine receptor D2 isoform long expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50216046(2-(4-(4-phenyl-1-piperazinyl)butyl)-1,2-benzisothi...)
Affinity DataKi:  360nMAssay Description:Displacement of [3H]-raclopride from human D2R expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50216046(2-(4-(4-phenyl-1-piperazinyl)butyl)-1,2-benzisothi...)
Affinity DataKi:  1.13E+3nMAssay Description:Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50216046(2-(4-(4-phenyl-1-piperazinyl)butyl)-1,2-benzisothi...)
Affinity DataKi:  1.13E+3nMAssay Description:Binding affinity to human D5RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed