BDBM50212764 CHEMBL233338::N-(1-(3-aminopropyl)-5-(N-methylcyclohexanecarboxamido)-1H-benzo[d]imidazol-2-yl)thiophene-2-carboxamide

SMILES CN(C(=O)C1CCCCC1)c1ccc2n(CCCN)c(NC(=O)c3cccs3)nc2c1

InChI Key InChIKey=PNKZMKLBCXJMOP-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50212764   

TargetEpidermal growth factor receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50212764(N-(1-(3-aminopropyl)-5-(N-methylcyclohexanecarboxa...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50212764(N-(1-(3-aminopropyl)-5-(N-methylcyclohexanecarboxa...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human ITK in presence of 3 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50212764(N-(1-(3-aminopropyl)-5-(N-methylcyclohexanecarboxa...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human ITK in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50212764(N-(1-(3-aminopropyl)-5-(N-methylcyclohexanecarboxa...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of TXKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50212764(N-(1-(3-aminopropyl)-5-(N-methylcyclohexanecarboxa...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of BTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50212764(N-(1-(3-aminopropyl)-5-(N-methylcyclohexanecarboxa...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human ITK in presence of 500 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50212764(N-(1-(3-aminopropyl)-5-(N-methylcyclohexanecarboxa...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50212764(N-(1-(3-aminopropyl)-5-(N-methylcyclohexanecarboxa...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50212764(N-(1-(3-aminopropyl)-5-(N-methylcyclohexanecarboxa...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LYNMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50212764(N-(1-(3-aminopropyl)-5-(N-methylcyclohexanecarboxa...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of TECMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50212764(N-(1-(3-aminopropyl)-5-(N-methylcyclohexanecarboxa...)
Affinity DataIC50: 2.40E+3nMAssay Description:Effect on human ITK in DT40 cells assessed as induction of calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50212764(N-(1-(3-aminopropyl)-5-(N-methylcyclohexanecarboxa...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of FGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50212764(N-(1-(3-aminopropyl)-5-(N-methylcyclohexanecarboxa...)
Affinity DataIC50: 320nMAssay Description:Inhibition of human ITK in presence of 20 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50212764(N-(1-(3-aminopropyl)-5-(N-methylcyclohexanecarboxa...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ECKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50212764(N-(1-(3-aminopropyl)-5-(N-methylcyclohexanecarboxa...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of BMXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50212764(N-(1-(3-aminopropyl)-5-(N-methylcyclohexanecarboxa...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human ITK by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed