BDBM50212261 CHEMBL3946139

SMILES CC(C)n1cnnc1-c1cccc(n1)N1Cc2ccc(OC[C@@H]3CN(C)CCO3)cc2C1=O

InChI Key InChIKey=NRGCVZHEQBOONX-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50212261   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50212261(CHEMBL3946139)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ASK1 catalytic domain (654 to 971 residues) expressed in baculovirus infected sf21 cells using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50212261(CHEMBL3946139)
Affinity DataEC50:  6.30nMAssay Description:Inhibition of human ASK1 expressed in HEK293 cells assessed as inhibition of H2O2-induced JNK phosphorylation preincubated for 30 mins followed by H2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2018
Entry Details Article
PubMed