BDBM50211497 (1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-[(1R,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide::CHEMBL226065

SMILES C[C@H]1CN(CC[C@@]11C=Cc2ccccc12)[C@@H]1CC[C@@H](C1)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=MGXIAUQCPAQVBR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50211497   

TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211497((1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}...)
Affinity DataIC50: 57nMAssay Description:Antagonist activity against human CCR2 receptor in human monocytes assessed as inhibition of chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211497((1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}...)
Affinity DataIC50: 1.40nMAssay Description:Displacement of [125]hMCP1 from human CCR2 receptor expressed in human monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211497((1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}...)
Affinity DataIC50: 2.30nMAssay Description:Antagonist activity against human CCR2 receptor assessed as inhibition of MCP1-induced calcium flux in human monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed