BDBM50211363 3-isopropyl-1H-pyrazole-5-carboxylic acid::5-Isopropyl-1H-pyrazole-3-carboxylic acid::5-isopropyl-3-carboxyl-pyrazole::CHEMBL238002

SMILES CC(C)c1cc(n[nH]1)C(O)=O

InChI Key InChIKey=CHWXKAHFWLSLOQ-UHFFFAOYSA-N

Data  1 KI  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50211363   

TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50211363(5-isopropyl-3-carboxyl-pyrazole | 5-Isopropyl-1H-p...)
Affinity DataEC50:  110nMAssay Description:Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50211363(5-isopropyl-3-carboxyl-pyrazole | 5-Isopropyl-1H-p...)
Affinity DataEC50:  4.17E+4nMAssay Description:Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50211363(5-isopropyl-3-carboxyl-pyrazole | 5-Isopropyl-1H-p...)
Affinity DataEC50:  110nMAssay Description:Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50211363(5-isopropyl-3-carboxyl-pyrazole | 5-Isopropyl-1H-p...)
Affinity DataEC50:  8.30E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50211363(5-isopropyl-3-carboxyl-pyrazole | 5-Isopropyl-1H-p...)
Affinity DataIC50: 2.60E+3nMAssay Description:Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Rat)
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50211363(5-isopropyl-3-carboxyl-pyrazole | 5-Isopropyl-1H-p...)
Affinity DataKi:  683nMAssay Description:Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed