BDBM50211267 CHEMBL3967137

SMILES OC(c1cnn(n1)C(=O)N1C[C@H](CC[C@@H]1Cc1ccccc1)OCC1CC1)(c1ccc(F)cc1)c1ccc(F)cc1

InChI Key InChIKey=LGBQVORQOWSIEF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50211267   

TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211267(CHEMBL3967137)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed
TargetMonoacylglycerol lipase ABHD6(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211267(CHEMBL3967137)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MB064 probe binding to ABHD6 in mouse brain membrane proteome preincubated for 30 mins followed by MB064 probe addition measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211267(CHEMBL3967137)
Affinity DataIC50: 79nMAssay Description:Inhibition of MB064 probe binding to DAGLalpha in mouse brain membrane proteome preincubated for 30 mins followed by MB064 probe addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed
TargetMonoacylglycerol lipase ABHD6(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211267(CHEMBL3967137)
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of human ABHD6 using 2-AG as natural substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed