BDBM50210271 7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-methoxyethoxy)-prop-1-ynyl)thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazole::CHEMBL223971

SMILES COCCOCC#Cc1cc(cs1)-c1[nH]nc-2c1Cc1ccc(Cn3cncn3)cc-21

InChI Key InChIKey=UVNBMNWTGOQKQF-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50210271   

TargetPlatelet-derived growth factor receptor alpha/beta(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210271(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)
Affinity DataIC50: 84nMAssay Description:Inhibition of PDGFR by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210271(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Flt1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210271(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of hERG expressed in HEK293 cells assessed as effect on ionic current by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210271(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)
Affinity DataIC50: 4nMAssay Description:Inhibition of Flt4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210271(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Flt3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210271(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)
Affinity DataIC50: 16nMAssay Description:Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210271(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of FynMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210271(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)
Affinity DataIC50: 9nMAssay Description:Inhibition of CSF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210271(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)
Affinity DataIC50: 12nMAssay Description:Inhibition of c-KitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210271(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)
Affinity DataIC50: 5nMAssay Description:Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by Western blotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210271(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210271(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of HckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210271(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210271(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)
Affinity DataIC50: 1.17E+4nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210271(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of hERG expressed in HEK293 cells assessed as effect on ionic current by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed