BDBM50209883 (2E)-4-(dimethylamino)-N-[7-ethoxy-4-({4-[(3-methylbenzyl)oxy]-3,6-dioxocyclohexa-1,4-dien-1-yl}amino)quinazolin-6-yl]but-2-enamide::CHEMBL241919

SMILES CCOc1cc2ncnc(NC3=CC(=O)C(OCc4cccc(C)c4)=CC3=O)c2cc1NC(=O)\C=C\CN(C)C

InChI Key InChIKey=FWQHTPQAWDKGBW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50209883   

TargetEpidermal growth factor receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209883((2E)-4-(dimethylamino)-N-[7-ethoxy-4-({4-[(3-methy...)
Affinity DataIC50: 173nMAssay Description:Inhibition of human EGFR in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209883((2E)-4-(dimethylamino)-N-[7-ethoxy-4-({4-[(3-methy...)
Affinity DataIC50: 189nMAssay Description:Inhibition of human VEGFR2 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209883((2E)-4-(dimethylamino)-N-[7-ethoxy-4-({4-[(3-methy...)
Affinity DataIC50: 24.9nMAssay Description:Inhibition of human EGFR in presence of 1 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209883((2E)-4-(dimethylamino)-N-[7-ethoxy-4-({4-[(3-methy...)
Affinity DataIC50: 613nMAssay Description:Inhibition of human VEGFR2 in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed