BDBM50209010 3,5-dichloro-2-hydroxy-N-(4-methoxy-biphenyl-3-yl)-benzenesulfonamide::CHEMBL399379::US20240398737, Compound BMS-303141

SMILES COc1ccc(cc1NS(=O)(=O)c1cc(Cl)cc(Cl)c1O)-c1ccccc1

InChI Key InChIKey=SIIPNDKXZOTLEA-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50209010   

TargetAcetyl-CoA carboxylase 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50209010(3,5-dichloro-2-hydroxy-N-(4-methoxy-biphenyl-3-yl)...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human ACC2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-citrate synthase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50209010(3,5-dichloro-2-hydroxy-N-(4-methoxy-biphenyl-3-yl)...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human recombinant ATP-citrate lyaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50209010(3,5-dichloro-2-hydroxy-N-(4-methoxy-biphenyl-3-yl)...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human ACC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-citrate synthase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50209010(3,5-dichloro-2-hydroxy-N-(4-methoxy-biphenyl-3-yl)...)
Affinity DataIC50: 377nMAssay Description:Inhibition of ATP citrate lyase (unknown origin) using sodium citrate as substrate by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details Article
PubMed
TargetATP-citrate synthase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50209010(3,5-dichloro-2-hydroxy-N-(4-methoxy-biphenyl-3-yl)...)
Affinity DataIC50: 442nMAssay Description:Inhibition of ATP citrate lyase (unknown origin) using sodium citrate as substrate after 60 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetATP-citrate synthase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50209010(3,5-dichloro-2-hydroxy-N-(4-methoxy-biphenyl-3-yl)...)
Affinity DataIC50: 500nMAssay Description:Inhibition of ACL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetATP-citrate synthase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50209010(3,5-dichloro-2-hydroxy-N-(4-methoxy-biphenyl-3-yl)...)
Affinity DataIC50: 460nMAssay Description:Inhibition of ACL (unknown origin) incubated for 30 mins in presence of ATP by luminescence based ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetATP-citrate synthase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50209010(3,5-dichloro-2-hydroxy-N-(4-methoxy-biphenyl-3-yl)...)
Affinity DataIC50: 445nMAssay Description:Table 4: ATP citrate lyase was obtained from Sino Biological Inc. Cat #11769-H07B, Lot #LC08DE1701. It was prepared from a DNA sequence encoding the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2025
Entry Details
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