BDBM50208187 CHEMBL3897116

SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2ccc(C)c2c(=O)n1-c1ccccc1

InChI Key InChIKey=JRRIJVZLPMMJSV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50208187   

LigandPNGBDBM50208187(CHEMBL3897116)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2018
Entry Details Article
PubMed
LigandPNGBDBM50208187(CHEMBL3897116)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2018
Entry Details Article
PubMed
LigandPNGBDBM50208187(CHEMBL3897116)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length p110alpha/recombinant human full length p85alpha using PIP2 as substrate preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50208187(CHEMBL3897116)
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length p110beta/recombinant human full length p85alpha using PIP2 as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50208187(CHEMBL3897116)
Affinity DataIC50: 65nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length p110gamma using PIP2 as substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50208187(CHEMBL3897116)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human N-terminal His-tagged full length p110delta/recombinant human full length p85alpha using PIP2 as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed