BDBM50208182 CHEMBL3900775

SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2c(ccc2c(=O)n1-c1ccccc1)C(F)(F)F

InChI Key InChIKey=VJIFSFPVRUQTLB-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50208182   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
RhôNe-Poulenc Rorer

Curated by ChEMBL

LigandBDBM50208182(CHEMBL3900775)Copy SMILESCopy InChI

Affinity DataIC50: 380nMAssay Description:Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
8/30/2018
Entry Details Article
Copy Entry DOIPubMed
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TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
RhôNe-Poulenc Rorer

Curated by ChEMBL

LigandBDBM50208182(CHEMBL3900775)Copy SMILESCopy InChI

Affinity DataIC50: 71nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
8/30/2018
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL