BDBM50208178 CHEMBL3925368

SMILES Nc1ncnc(NC(CC(F)(F)F)c2nn3cccc3c(=O)n2-c2ccccc2)c1C#N

InChI Key InChIKey=XDNAVNZQJUPKNP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50208178   

LigandPNGBDBM50208178(CHEMBL3925368)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2018
Entry Details Article
PubMed
LigandPNGBDBM50208178(CHEMBL3925368)
Affinity DataIC50: 17nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2018
Entry Details Article
PubMed
LigandPNGBDBM50208178(CHEMBL3925368)
Affinity DataIC50: 51nMAssay Description:Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2018
Entry Details Article
PubMed
LigandPNGBDBM50208178(CHEMBL3925368)
Affinity DataIC50: 610nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2018
Entry Details Article
PubMed