BDBM50208166 CHEMBL3901527

SMILES C[C@@H](C1=Nn2cccc2C(=O)N1c3ccccc3)Nc4c(c(ncn4)N)C#N

InChI Key InChIKey=MDMKWYWCJZMADI-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50208166   

LigandPNGBDBM50208166(CHEMBL3901527)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50208166(CHEMBL3901527)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50208166(CHEMBL3901527)
Affinity DataIC50: 640nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length p110beta/recombinant human full length p85alpha using PIP2 as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50208166(CHEMBL3901527)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length p110alpha/recombinant human full length p85alpha using PIP2 as substrate preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50208166(CHEMBL3901527)
Affinity DataIC50: 280nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length p110gamma using PIP2 as substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50208166(CHEMBL3901527)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of recombinant human N-terminal His-tagged full length p110delta/recombinant human full length p85alpha using PIP2 as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)