BDBM50207561 CHEMBL396097::Class IIa HDAC inhibitor, Compound 6::N-hydroxy-2,2-diphenylacetamide

SMILES ONC(=O)C(c1ccccc1)c1ccccc1

InChI Key InChIKey=OFSBBVCLWMCGNY-UHFFFAOYSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50207561   

TargetHistone deacetylase 8(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50207561(N-hydroxy-2,2-diphenylacetamide | CHEMBL396097 | C...)
Affinity DataIC50: 6.60E+4nMAssay Description:Inhibition of recombinant HDAC8 expressed in baculovirus after 10 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50207561(N-hydroxy-2,2-diphenylacetamide | CHEMBL396097 | C...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human HDAC8 using Boc-Lys (trifluoroacetyl)-AMC as substrate preincubated for 1 hr followed by substrate addition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Bharati Vidyapeeth'S College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50207561(N-hydroxy-2,2-diphenylacetamide | CHEMBL396097 | C...)
Affinity DataIC50: 220nMAssay Description:Inhibition of recombinant human HDAC4 using Boc-Lys (trifluoroacetyl)-AMC as substrate preincubated for 1 hr followed by substrate addition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
Charles River Discovery (Previously Biofocus)

Curated by ChEMBL
LigandPNGBDBM50207561(N-hydroxy-2,2-diphenylacetamide | CHEMBL396097 | C...)
Affinity DataIC50: 510nMAssay Description:Inhibition of human C-terminal His-tagged HDAC9 (604 to 1066 residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys-TFA as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Bharati Vidyapeeth'S College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50207561(N-hydroxy-2,2-diphenylacetamide | CHEMBL396097 | C...)
Affinity DataIC50: 250nMAssay Description:Inhibition of HDAC4 catalytic domain (648 to 1057 residues) (unknown origin) using Boc-Lys-TFA as substrate measured after 60 mins by fluorescence as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
Charles River Discovery (Previously Biofocus)

Curated by ChEMBL
LigandPNGBDBM50207561(N-hydroxy-2,2-diphenylacetamide | CHEMBL396097 | C...)
Affinity DataIC50: 160nMAssay Description:Inhibition of human C-terminal His-tagged HDAC5 catalytic domain (656 to 1122 residues) expressed in baculovirus infected Sf9 insect cells using Boc-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
Charles River Discovery (Previously Biofocus)

Curated by ChEMBL
LigandPNGBDBM50207561(N-hydroxy-2,2-diphenylacetamide | CHEMBL396097 | C...)
Affinity DataIC50: 650nMAssay Description:Inhibition of human N-terminal GST-tagged HDAC7 (518 to end residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys-TFA as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Charles River Discovery (Previously Biofocus)

Curated by ChEMBL
LigandPNGBDBM50207561(N-hydroxy-2,2-diphenylacetamide | CHEMBL396097 | C...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of full length recombinant human C-terminal His-tagged HDAC3/N-terminal GST-tagged NCOR2 co-expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50207561(N-hydroxy-2,2-diphenylacetamide | CHEMBL396097 | C...)
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of human full length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cells using Boc-Lys-TFA as substrate measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Charles River Discovery (Previously Biofocus)

Curated by ChEMBL
LigandPNGBDBM50207561(N-hydroxy-2,2-diphenylacetamide | CHEMBL396097 | C...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of recombinant human HDAC6 expressed in HEK293 cells using Lys-Ac-AMC as substrate measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Biofocus

Curated by ChEMBL
LigandPNGBDBM50207561(N-hydroxy-2,2-diphenylacetamide | CHEMBL396097 | C...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant full length HDAC3-NCoR2 using Lys_Ac_AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetIsoform 5 of Histone deacetylase 7 (5) 18-991](Human)
University of Queensland

LigandPNGBDBM50207561(N-hydroxy-2,2-diphenylacetamide | CHEMBL396097 | C...)
Affinity DataIC50: 354nMpH: 8.0Assay Description:Fluorescence readings were carried out on a CytofluorR Series 4000 fluorescence multiwell plate reader (Perspective Biosystems). Stock solutions of t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2017
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Charles River Discovery (Previously Biofocus)

Curated by ChEMBL
LigandPNGBDBM50207561(N-hydroxy-2,2-diphenylacetamide | CHEMBL396097 | C...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged HDAC6 (438-915) expressed in baculovirus after 10 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50207561(N-hydroxy-2,2-diphenylacetamide | CHEMBL396097 | C...)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of recombinant C-terminal FLAG-tagged HDAC2 expressed in baculovirus after 10 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Bharati Vidyapeeth'S College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50207561(N-hydroxy-2,2-diphenylacetamide | CHEMBL396097 | C...)
Affinity DataIC50: 750nMAssay Description:Inhibition of human recombinant N-terminal FLAG-tagged HDAC4 (612-1034) expressed in baculovirus after 10 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50207561(N-hydroxy-2,2-diphenylacetamide | CHEMBL396097 | C...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant C-terminal FLAG-tagged HDAC1 expressed in baculovirus after 10 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
Charles River Discovery (Previously Biofocus)

Curated by ChEMBL
LigandPNGBDBM50207561(N-hydroxy-2,2-diphenylacetamide | CHEMBL396097 | C...)
Affinity DataIC50: 390nMAssay Description:Inhibition of human recombinant N-terminal FLAG-tagged HDAC7 (438-915) expressed in baculovirus after 10 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50207561(N-hydroxy-2,2-diphenylacetamide | CHEMBL396097 | C...)
Affinity DataIC50: 6.60E+4nMAssay Description:Inhibition of human HDAC8 by [3H]acetyl histone peptide assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
Charles River Discovery (Previously Biofocus)

Curated by ChEMBL
LigandPNGBDBM50207561(N-hydroxy-2,2-diphenylacetamide | CHEMBL396097 | C...)
Affinity DataIC50: 140nMAssay Description:Inhibition of human recombinant N-terminal FLAG-tagged HDAC5 (620-1122) expressed in baculovirus after 10 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50207561(N-hydroxy-2,2-diphenylacetamide | CHEMBL396097 | C...)
Affinity DataIC50: 1.00E+4nMpH: 8.0Assay Description:Fluorescence readings were carried out on a CytofluorR Series 4000 fluorescence multiwell plate reader (Perspective Biosystems). Stock solutions of t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2017
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Charles River Discovery (Previously Biofocus)

Curated by ChEMBL
LigandPNGBDBM50207561(N-hydroxy-2,2-diphenylacetamide | CHEMBL396097 | C...)
Affinity DataIC50: 5.00E+3nMpH: 8.0Assay Description:Fluorescence readings were carried out on a CytofluorR Series 4000 fluorescence multiwell plate reader (Perspective Biosystems). Stock solutions of t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2017
Entry Details Article
PubMed