BDBM50207498 1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(thiophen-3-yl)urea::CHEMBL376307::N-[4-(3-amino-1H-indazol-4-yl)-phenyl]-N'-thiophen-3-ylurea

SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccsc4)cc3)c12

InChI Key InChIKey=OPVYNMNWPXOEJX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50207498   

TargetMast/stem cell growth factor receptor Kit(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50207498(N-[4-(3-amino-1H-indazol-4-yl)-phenyl]-N'-thiophen...)
Affinity DataIC50: 42nMAssay Description:Inhibition of c-Kit by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50207498(N-[4-(3-amino-1H-indazol-4-yl)-phenyl]-N'-thiophen...)
Affinity DataIC50: 15nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50207498(N-[4-(3-amino-1H-indazol-4-yl)-phenyl]-N'-thiophen...)
Affinity DataIC50: 5nMAssay Description:Inhibition of FLT3 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50207498(N-[4-(3-amino-1H-indazol-4-yl)-phenyl]-N'-thiophen...)
Affinity DataIC50: 42nMAssay Description:Inhibition of c-Kit by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed