BDBM50206955 CHEMBL3923127

SMILES C[C@](O)(c1cncc(c1)-c1nc2ccc(F)cn2c1C1CC1)C(F)(F)F

InChI Key InChIKey=OWGUKRPUVVBJPH-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50206955   

TargetCytochrome P450 11B2, mitochondrial(Human)
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206955(CHEMBL3923127)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of human CYP11B2-CLE9 expressed in Chinese hamster V79 cells using 11-deoxycorticosterone as substrate preincubated for 1 hr followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2018
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206955(CHEMBL3923127)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP17 expressed in African green monkey COS7 cells using 17-hydroxypregnenolone as substrate preincubated for 1 hr followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2018
Entry Details Article
PubMed
TargetAromatase(Human)
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206955(CHEMBL3923127)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of CYP19 (unknown origin) using MFC as substrate and NADPH as cofactor preincubated for 10 mins with cofactor followed by substrate/enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2018
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206955(CHEMBL3923127)
Affinity DataIC50: 460nMAssay Description:Inhibition of human CYP11B1-8C7 expressed in Chinese hamster V79 cells using 11-deoxycortisol as substrate preincubated for 1 hr followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2018
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206955(CHEMBL3923127)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of hepatic CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2018
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206955(CHEMBL3923127)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of hepatic CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2018
Entry Details Article
PubMed
TargetSteroid 21-hydroxylase(Human)
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206955(CHEMBL3923127)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP21 expressed in African green monkey COS7 cells using 17-hydroxypregnenolone as substrate preincubated for 1 hr followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2018
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206955(CHEMBL3923127)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of hepatic CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2018
Entry Details Article
PubMed