BDBM50206219 9-(3-(piperidin-1-yl)propoxy)-6-(3-(trifluoromethyl)phenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline::CHEMBL241473

SMILES FC(F)(F)c1cccc(c1)C1CN2CCCC2c2cc(OCCCN3CCCCC3)ccc12

InChI Key InChIKey=VKNVUSIACZZCCO-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50206219   

TargetHistamine H3 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50206219(9-(3-(piperidin-1-yl)propoxy)-6-(3-(trifluoromethy...)
Affinity DataKi:  2nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50206219(9-(3-(piperidin-1-yl)propoxy)-6-(3-(trifluoromethy...)
Affinity DataKi:  21.7nMAssay Description:Displacement of [3H]citalopram from rat brain SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50206219(9-(3-(piperidin-1-yl)propoxy)-6-(3-(trifluoromethy...)
Affinity DataKi:  24nMAssay Description:Displacement of N-[3H]-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed