BDBM50205848 CHEMBL3948381::US10280165, Example 56

SMILES FC(F)(F)c1cc(Cl)n(Cc2cc(=O)n3c(cc(cc3n2)C(F)(F)F)[C@@H]2C[C@H]2C#N)n1

InChI Key InChIKey=XUFBUSLDAAZEOP-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50205848   

TargetGlutamate receptor 2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50205848(CHEMBL3948381 | US10280165, Example 56)
Affinity DataEC50:  2.70E+4nMAssay Description:Positive allosteric modulation of human GluA2 receptor flip isoform assessed as increase in glutamate-induced calcium flux measured at time interval ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50205848(CHEMBL3948381 | US10280165, Example 56)
Affinity DataEC50:  120nMAssay Description:Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50205848(CHEMBL3948381 | US10280165, Example 56)
Affinity DataEC50:  1.60E+4nMAssay Description:Positive allosteric modulation of human GluA2 receptor flop isoform assessed as increase in glutamate-induced calcium flux measured at time interval ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50205848(CHEMBL3948381 | US10280165, Example 56)
Affinity DataEC50:  123nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
Go to US Patent