BDBM50205790 (E)-2-(2,4-difluorostyryl)-5-(phenylsulfinyl)pyridine::CHEMBL240887

SMILES Fc1ccc(\C=C\c2ccc(cn2)S(=O)c2ccccc2)c(F)c1

InChI Key InChIKey=DLASHKPJUVPKQY-UHFFFAOYSA-N

Data  12 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50205790   

Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50205790((E)-2-(2,4-difluorostyryl)-5-(phenylsulfinyl)pyrid...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50205790((E)-2-(2,4-difluorostyryl)-5-(phenylsulfinyl)pyrid...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50205790((E)-2-(2,4-difluorostyryl)-5-(phenylsulfinyl)pyrid...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]mesurgeline from human 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50205790((E)-2-(2,4-difluorostyryl)-5-(phenylsulfinyl)pyrid...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]mesurgeline from human 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50205790((E)-2-(2,4-difluorostyryl)-5-(phenylsulfinyl)pyrid...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50205790((E)-2-(2,4-difluorostyryl)-5-(phenylsulfinyl)pyrid...)
Affinity DataKi: >2.00E+3nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50205790((E)-2-(2,4-difluorostyryl)-5-(phenylsulfinyl)pyrid...)
Affinity DataKi: >2.00E+3nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50205790((E)-2-(2,4-difluorostyryl)-5-(phenylsulfinyl)pyrid...)
Affinity DataKi: >2.00E+3nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50205790((E)-2-(2,4-difluorostyryl)-5-(phenylsulfinyl)pyrid...)
Affinity DataKi:  2.40E+3nMAssay Description:Displacement of [3H]mesurgeline from human 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50205790((E)-2-(2,4-difluorostyryl)-5-(phenylsulfinyl)pyrid...)
Affinity DataKi:  4.20E+3nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50205790((E)-2-(2,4-difluorostyryl)-5-(phenylsulfinyl)pyrid...)
Affinity DataKi:  6.50E+3nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50205790((E)-2-(2,4-difluorostyryl)-5-(phenylsulfinyl)pyrid...)
Affinity DataKi:  6.50E+3nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed