BDBM50204862 CHEMBL436521::N-(2-((4-benzylpiperidin-1-yl)methyl)-3H-benzo[d]imidazol-5-yl)methanesulfonamide::N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimidazol-5-yl]-methanesulfonamide

SMILES CS(=O)(=O)Nc1ccc2nc(CN3CCC(Cc4ccccc4)CC3)[nH]c2c1

InChI Key InChIKey=WAUCNDQNILDAKL-UHFFFAOYSA-N

Data  2 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50204862   

TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50204862(N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimida...)
Affinity DataIC50: 3.5nMAssay Description:Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50204862(N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimida...)
Affinity DataIC50: 3.5nMAssay Description:Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50204862(N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimida...)
Affinity DataIC50: 8.60nMAssay Description:Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50204862(N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimida...)
Affinity DataIC50: 1.50E+3nMAssay Description:In vitro inhibitory activity against alpha-1 adrenergic receptor binding to rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50204862(N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimida...)
Affinity DataIC50: 1.90nMAssay Description:In vitro inhibition of Glu/Gly stimulated [Ca2+] influx in LtK-cells expressing the hNR1a/NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50204862(N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimida...)
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at human NR1a/NR2B receptor expressed in mouse fibroblast LMTK cells assessed as inhibition of Glu/Gly induced Ca2+ influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50204862(N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimida...)
Affinity DataIC50: 50nMAssay Description:Antagonist activity against NR1a/NR2B receptor transfected in human HEK293 cells assessed as inhibition of NMDA-induced Ca2+ influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50204862(N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimida...)
Affinity DataKi:  0.990nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50204862(N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimida...)
Affinity DataKi:  0.990nMAssay Description:Binding affinity to NR1/NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed