BDBM50204596 CHEMBL3977461::US10285989, Example 30

SMILES CC(C)[C@@H](NC(=O)c1cc(=O)[nH]c(n1)N(C)C)c1ccc(SC(F)(F)F)cc1

InChI Key InChIKey=RTAPSDDIHRJROQ-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50204596   

TargetPhosphodiesterase(Rhesus macaque)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50204596(CHEMBL3977461 | US10285989, Example 30)
Affinity DataKi:  0.190nMAssay Description:Inhibition of rhesus monkey PDE2A3 expressed in AD293 cells using FAM-labeled cAMP as substrate after 60 mins in presence of cGMP by florescence pola...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details Article
PubMed
TargetPhosphodiesterase(Rhesus macaque)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50204596(CHEMBL3977461 | US10285989, Example 30)
Affinity DataKi:  0.190nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetPhosphodiesterase(Rhesus macaque)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50204596(CHEMBL3977461 | US10285989, Example 30)
Affinity DataKi:  0.220nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50204596(CHEMBL3977461 | US10285989, Example 30)
Affinity DataKi:  0.370nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50204596(CHEMBL3977461 | US10285989, Example 30)
Affinity DataKi: <5.10nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent