BDBM50204290 CHEMBL3979920::US11077111, Compound IIIa::US20230295171, Example 102

SMILES Cn1cc(cn1)c2c3c(c(c(n2)N[C@@H]4CCCC[C@@H]4N)F)CNC3=O

InChI Key InChIKey=MJHOMTRKVMKCNE-UHFFFAOYSA-N

Data  20 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50204290   

TargetTyrosine-protein kinase SYK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human C-terminal 6His-tagged SYK (356 to 635 residues) expressed in Sf9 insect cells using 5-carboxyfluorescein(FAM)-EEPLYWSFPAKKK-NH2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase SYK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50: 3.98nMAssay Description:YK protein is prepared from cDNA encoding human spleen tyrosine kinase and is expressed in insect cells using a baculovirus expression vector. The cD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase SYK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50: 10nMAssay Description:YK protein is prepared from cDNA encoding human spleen tyrosine kinase and is expressed in insect cells using a baculovirus expression vector. The cD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase SYK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50: 2.51nMAssay Description:YK protein is prepared from cDNA encoding human spleen tyrosine kinase and is expressed in insect cells using a baculovirus expression vector. The cD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase(Red fox)
Bayer Animal Health

US Patent
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50: 4.62E+3nMAssay Description:A radiometric protein kinase assay was used for measuring the kinase activity of the Dog (Canis lupus familiaris) IRAK4, JAK1, JAK2, SYK kinases. All...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase(Dog)
Bayer Animal Health

US Patent
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50: 4.83E+3nMAssay Description:A radiometric protein kinase assay was used for measuring the kinase activity of the Dog (Canis lupus familiaris) IRAK4, JAK1, JAK2, SYK kinases. All...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase(Dog)
Bayer Animal Health

US Patent
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50: 3.07E+3nMAssay Description:A radiometric protein kinase assay was used for measuring the kinase activity of the Dog (Canis lupus familiaris) IRAK4, JAK1, JAK2, SYK kinases. All...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetInterleukin 1 receptor associated kinase 4(Dog)
Bayer Animal Health

US Patent
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50: 17.7nMAssay Description:A radiometric protein kinase assay was used for measuring the kinase activity of the Dog (Canis lupus familiaris) IRAK4, JAK1, JAK2, SYK kinases. All...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant full length N-terminal GST-tagged SYK cytoplasmic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 4(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50: 76nMAssay Description:Inhibition of human recombinant GST-tagged PAK4 catalytic domain (295 to 591 residues) expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2018
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human N-terminal 6His-tagged FLT3 (564 to 993 residues) expressed in Sf9 insect cells using 5-carboxyfluorescein(FAM)-KKKKEEIYFFFG-NH2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2018
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataEC50:  9.80nMAssay Description:Inhibition of SYK in TgM-stimulated human Ramos cells expressing RA1/GFP-tagged BLNK assessed as reduction in RA1/GFP-tagged BLNK phosphorylation pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase ZAP-70(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50: 75nMAssay Description:Inhibition of human full length N-terminal GST-tagged ZAP-70 (1 to 619 residues) expressed in baculovirus expression system using ULight peptide as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2018
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50: 88nMAssay Description:Inhibition of human recombinant His-tagged VEGFR2 cytoplasmic domain (789 to1356 residues) expressed in baculovirus expression system by Z'-LYTE assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2018
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant GST-tagged RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2018
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50: 114nMAssay Description:Inhibition of human recombinant GST-tagged JAK3 expressed in baculovirus expression system using 5-carboxyfluorescein(FAM)-EEPLYWSFPAKKK-NH2 as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2018
Entry Details Article
PubMed
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50: 226nMAssay Description:Inhibition of human recombinant full length N-terminal GST-tagged PHKG2 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2018
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fer(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50: 51nMAssay Description:Inhibition of human recombinant FER cytoplasmic domain (541 to 822 residues) expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2018
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant full length His-tagged CHK1 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2018
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50: 135nMAssay Description:Inhibition of human N-terminal 6His-tagged VEGFR2 (807 to 1171 residues) expressed in Sf9 insect cells using 5-carboxyfluorescein(FAM)-EEPLYWSFPAKKK-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2018
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50: 31nMAssay Description:Inhibition of human recombinant GST-tagged EPHA1 cytoplasmic domain (568 to 976 residues) expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2018
Entry Details Article
PubMed