BDBM50204014 CHEMBL3944424::US10059667, Example 27

SMILES C[C@@H]([C@@H](C1CC1)c1cccc(OCC2CN(C2)C(C)c2cc(ccc2C(F)(F)F)C(F)(F)F)c1)C(O)=O

InChI Key InChIKey=FWRWCJVLQDKKRG-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50204014   

TargetFree fatty acid receptor 1(Human)
Shanghai University

Curated by ChEMBL
LigandPNGBDBM50204014(CHEMBL3944424 | US10059667, Example 27)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells coexpressing NFAT BLA assessed as increase in intracellular Ca2+ flux by fluo-4-AM dye based F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2018
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Shanghai University

Curated by ChEMBL
LigandPNGBDBM50204014(CHEMBL3944424 | US10059667, Example 27)
Affinity DataEC50:  0.300nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetFree fatty acid receptor 1(Human)
Shanghai University

Curated by ChEMBL
LigandPNGBDBM50204014(CHEMBL3944424 | US10059667, Example 27)
Affinity DataEC50:  7.60nMT: 2°CAssay Description:The assay was performed in 96-well format. HEK cells stably expressing human GPR40 were plated to be 60-80% confluent within 72 h. After 72 h, the pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent