BDBM50203941 (S)-pyrrolidin-3-yl-(tetrahydro-pyran-4-yl)-(2-trifluoromethyl-benzyl)-amine::CHEMBL442272

SMILES FC(F)(F)c1ccccc1CN([C@H]1CCNC1)C1CCOCC1

InChI Key InChIKey=NUAORYLXEWKQRZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50203941   

LigandPNGBDBM50203941((S)-pyrrolidin-3-yl-(tetrahydro-pyran-4-yl)-(2-tri...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203941((S)-pyrrolidin-3-yl-(tetrahydro-pyran-4-yl)-(2-tri...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203941((S)-pyrrolidin-3-yl-(tetrahydro-pyran-4-yl)-(2-tri...)
Affinity DataIC50: 21nMAssay Description:Inhibition of [3H]5-HT from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203941((S)-pyrrolidin-3-yl-(tetrahydro-pyran-4-yl)-(2-tri...)
Affinity DataIC50: 9nMAssay Description:Inhibition of [3H]NA from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203941((S)-pyrrolidin-3-yl-(tetrahydro-pyran-4-yl)-(2-tri...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of [3H]DA from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed