BDBM50203533 (6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-carbonyl)-5-azaspiro[2.5]octane-7-carboxamide::(6S,7S)-N-hydroxy-6-{[(3R)-3-phenylpyrrolidin-1-yl]carbonyl}-5-azaspiro[2.5]octane-7-carboxamide::CHEMBL221698

SMILES ONC(=O)[C@H]1CC2(CC2)CN[C@@H]1C(=O)N1CC[C@@H](C1)c1ccccc1

InChI Key InChIKey=XKPUKZQRNSFQLM-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50203533   

TargetMatrix metalloproteinase-9(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50: 92nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50: 97nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50: 960nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50: 960nMAssay Description:Inhibition of MMP-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50: 92nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50: 97nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed