BDBM50203074 4-((4-ethoxy-1-methyl-1H-indol-3-yl)methylene)-3-(4-methyl-1,2,3-thiadiazol-5-yl)-1H-pyrazol-5(4H)-one::CHEMBL398610

SMILES CCOc1cccc2n(C)cc(C=c3c(=O)[nH][nH]\c3=c3/snnc3=C)c12

InChI Key InChIKey=PCIMPOMGHFNGMS-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50203074   

LigandPNGBDBM50203074(4-((4-ethoxy-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Affinity DataIC50: 16nMAssay Description:Inhibition of VEGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50203074(4-((4-ethoxy-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Affinity DataIC50: 47nMAssay Description:Inhibition of ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50203074(4-((4-ethoxy-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Affinity DataIC50: 998nMAssay Description:Inhibition of GST-tagged intracellular domain of IR by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50203074(4-((4-ethoxy-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Affinity DataIC50: 463nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203074(4-((4-ethoxy-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50203074(4-((4-ethoxy-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Affinity DataIC50: 36nMAssay Description:Inhibition of TRK AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50203074(4-((4-ethoxy-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Affinity DataIC50: 19nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50203074(4-((4-ethoxy-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of cMetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50203074(4-((4-ethoxy-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203074(4-((4-ethoxy-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Affinity DataIC50: 38nMAssay Description:Inhibition of human cytoplasmic VEGFR2 expressed in baculovirus after 15 mins by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50203074(4-((4-ethoxy-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Affinity DataIC50: 300nMAssay Description:Inhibition of nucleophosmin-fused ALK autophosphorylation in human Karpas299 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50203074(4-((4-ethoxy-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Affinity DataIC50: 36nMAssay Description:Inhibition of human cytoplasmic domain of VEGFR-2 by time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed