BDBM50202653 CHEMBL3913503::US10730889, Example 409::US11485745, Example 409

SMILES CC1(CC(=O)N2CCC3(CC3CNC(=O)N3Cc4ccncc4C3)CC2)COC1

InChI Key InChIKey=XTLQWWOBQUJTIR-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50202653   

TargetNicotinamide phosphoribosyltransferase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50202653(CHEMBL3913503 | US10730889, Example 409 | US114857...)
Affinity DataIC50: 48nMAssay Description:Inhibition of human full length C-terminal His6-tagged NAMPT expressed in Escherichia coli Rosetta (DE3) cells using nicotinamide as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2018
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50202653(CHEMBL3913503 | US10730889, Example 409 | US114857...)
Affinity DataIC50: 11nMAssay Description:Inhibition of NAMPT in human A2780 cells assessed as decrease in cell viability after 72 hrs by SRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2018
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50202653(CHEMBL3913503 | US10730889, Example 409 | US114857...)
Affinity DataIC50: 1.00E+4nMAssay Description:Reversible inhibition of CYP2C9 in human liver microsomes using (S)-warfarin as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2018
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50202653(CHEMBL3913503 | US10730889, Example 409 | US114857...)
Affinity DataIC50: 46.7nMAssay Description:NAMPT Protein Purification. Recombinant His-tagged NAMPT was produced in E. coli cells, purified over a Ni column, and further purified over a size-e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2021
Entry Details
Go to US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50202653(CHEMBL3913503 | US10730889, Example 409 | US114857...)
Affinity DataIC50: 11.9nMAssay Description:NAMPT Protein Purification. Recombinant His-tagged NAMPT was produced in E. coli cells, purified over a Ni column, and further purified over a size-e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2021
Entry Details
Go to US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50202653(CHEMBL3913503 | US10730889, Example 409 | US114857...)
Affinity DataIC50: 46.7nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 17.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
Go to US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50202653(CHEMBL3913503 | US10730889, Example 409 | US114857...)
Affinity DataIC50: 11.9nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 17.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
Go to US Patent