BDBM50202086 CHEMBL219142::N-[(E)-5-hydroxy-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}acetamide

SMILES O[C@@]12CC3CC(C1)[C@H](NC(=O)CN1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2

InChI Key

Data  4 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50202086   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202086(N-[(E)-5-hydroxy-2-adamantyl]-2-{4-[5-(trifluorome...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells by FPIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202086(N-[(E)-5-hydroxy-2-adamantyl]-2-{4-[5-(trifluorome...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against rat 11beta-HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202086(N-[(E)-5-hydroxy-2-adamantyl]-2-{4-[5-(trifluorome...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against mouse 11beta-HSD2 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202086(N-[(E)-5-hydroxy-2-adamantyl]-2-{4-[5-(trifluorome...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against human 11beta-HSD2 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202086(N-[(E)-5-hydroxy-2-adamantyl]-2-{4-[5-(trifluorome...)
Affinity DataKi:  6nMAssay Description:Inhibitory activity against rat 11beta-HSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202086(N-[(E)-5-hydroxy-2-adamantyl]-2-{4-[5-(trifluorome...)
Affinity DataKi:  8nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coli by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202086(N-[(E)-5-hydroxy-2-adamantyl]-2-{4-[5-(trifluorome...)
Affinity DataKi:  8nMAssay Description:Inhibition of human 11beta-HSD-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202086(N-[(E)-5-hydroxy-2-adamantyl]-2-{4-[5-(trifluorome...)
Affinity DataKi:  34nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coli by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed