BDBM50201251 CHEMBL391362::N-((5R,6S)-2,4-dioxo-1,3-diaza-spiro[4.5]dec-6-yl)-4-(2-methyl-quinolin-4-ylmethoxy)-benzamide

SMILES Cc1cc(COc2ccc(cc2)C(=O)N[C@H]2CCCC[C@@]22NC(=O)NC2=O)c2ccccc2n1

InChI Key InChIKey=SXQXJOREJVFQQR-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50201251   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50201251(N-((5R,6S)-2,4-dioxo-1,3-diaza-spiro[4.5]dec-6-yl)...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of porcine TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50201251(N-((5R,6S)-2,4-dioxo-1,3-diaza-spiro[4.5]dec-6-yl)...)
Affinity DataKi: >2.13E+3nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50201251(N-((5R,6S)-2,4-dioxo-1,3-diaza-spiro[4.5]dec-6-yl)...)
Affinity DataKi: >3.33E+3nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50201251(N-((5R,6S)-2,4-dioxo-1,3-diaza-spiro[4.5]dec-6-yl)...)
Affinity DataKi: >4.95E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50201251(N-((5R,6S)-2,4-dioxo-1,3-diaza-spiro[4.5]dec-6-yl)...)
Affinity DataKi: >5.03E+3nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed