BDBM50201243 (5R,6S)-2,4-dioxo-1,3-diaza-spiro[4.6]undecane-6-carboxylic acid [4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-amide::CHEMBL245382

SMILES Cc1cc(COc2ccc(NC(=O)[C@H]3CCCCC[C@@]33NC(=O)NC3=O)cc2)c2ccccc2n1

InChI Key InChIKey=FXJADKGLMYYRPW-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50201243   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50201243((5R,6S)-2,4-dioxo-1,3-diaza-spiro[4.6]undecane-6-c...)
Affinity DataIC50: 270nMAssay Description:Inhibition of porcine TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50201243((5R,6S)-2,4-dioxo-1,3-diaza-spiro[4.6]undecane-6-c...)
Affinity DataKi: >2.13E+3nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50201243((5R,6S)-2,4-dioxo-1,3-diaza-spiro[4.6]undecane-6-c...)
Affinity DataKi: >3.33E+3nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50201243((5R,6S)-2,4-dioxo-1,3-diaza-spiro[4.6]undecane-6-c...)
Affinity DataKi: >4.95E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50201243((5R,6S)-2,4-dioxo-1,3-diaza-spiro[4.6]undecane-6-c...)
Affinity DataKi: >5.03E+3nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed