BDBM50201021 CHEMBL3966599::US10155727, Example 2::USRE49517, Example 2

SMILES Cn1ccc(Cn2cc(cn2)-c2ccc(Cl)c(OC(F)F)c2)n1

InChI Key InChIKey=CRYKKCVVHRIZJU-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50201021   

TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201021(CHEMBL3966599 | US10155727, Example 2 | USRE49517,...)
Affinity DataIC50: 78nMAssay Description:Antagonist activity at Wistar rat brain NR2B assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured after 90 secsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201021(CHEMBL3966599 | US10155727, Example 2 | USRE49517,...)
Affinity DataIC50: 2.46E+3nMAssay Description:Antagonist activity at human NR2B expressed in HEK293 cells co-expressing NRI assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201021(CHEMBL3966599 | US10155727, Example 2 | USRE49517,...)
Affinity DataIC50: 8.08E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201021(CHEMBL3966599 | US10155727, Example 2 | USRE49517,...)
Affinity DataIC50: 78.4nMAssay Description:After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4° C. The pellet was resuspended in 5 ml of 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201021(CHEMBL3966599 | US10155727, Example 2 | USRE49517,...)
Affinity DataIC50: 2.46E+3nMAssay Description:The medium was removed and the cells were loaded with 200 μl loading buffer (Molecular Devices) in Mg2+-free HBPS containing 100 μM 7-CKA a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201021(CHEMBL3966599 | US10155727, Example 2 | USRE49517,...)
Affinity DataIC50: 78.4nMAssay Description:After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201021(CHEMBL3966599 | US10155727, Example 2 | USRE49517,...)
Affinity DataIC50: 8.08E+3nMAssay Description:Binding was terminated by filtration of the incubated membrane preparations using Filtermat B (Pharmacia, Uppsala Sweden) and a Micro Cell Harvester ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent