BDBM50200978 CHEMBL3956037::US10087187, Compound 58

SMILES CN1CCN(Cc2c(Nc3c(C)nc4c(N)cc(nn34)N3CCOCC3)cccc2C(F)(F)F)CC1

InChI Key InChIKey=BHDJOPWZGIPZLV-UHFFFAOYSA-N

Data  2 IC50  10 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50200978   

LigandPNGBDBM50200978(CHEMBL3956037 | US10087187, Compound 58)
Affinity DataKd:  0.400nMAssay Description:Binding affinity to human PI3Kbeta (118 to 1070 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
LigandPNGBDBM50200978(CHEMBL3956037 | US10087187, Compound 58)
Affinity DataIC50: 17nMAssay Description:Inhibition of PI3Kbeta in human PC3 cells assessed as suppression of AKT phosphorylation at Thr308 after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50200978(CHEMBL3956037 | US10087187, Compound 58)
Affinity DataKd:  2.14E+4nMAssay Description:Binding affinity to human MTOR (1382 to 2549 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
LigandPNGBDBM50200978(CHEMBL3956037 | US10087187, Compound 58)
Affinity DataKd:  20nMAssay Description:Binding affinity to human PI3Kdelta (108 to 1044 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
LigandPNGBDBM50200978(CHEMBL3956037 | US10087187, Compound 58)
Affinity DataIC50: 21nMAssay Description:Inhibition of PI3Kbeta in human PC3 cells assessed as suppression of AKT phosphorylation at Ser473 after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
LigandPNGBDBM50200978(CHEMBL3956037 | US10087187, Compound 58)
Affinity DataKd:  4.27E+3nMAssay Description:Binding affinity to human PI3Kalpha (108 to 1068 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
LigandPNGBDBM50200978(CHEMBL3956037 | US10087187, Compound 58)
Affinity DataKd:  1.23E+4nMAssay Description:Binding affinity to human PI3Kgamma (144 to 1102 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2018
Entry Details Article
PubMed
LigandPNGBDBM50200978(CHEMBL3956037 | US10087187, Compound 58)
Affinity DataKd:  4.27E+3nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

LigandPNGBDBM50200978(CHEMBL3956037 | US10087187, Compound 58)
Affinity DataKd:  0.400nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

LigandPNGBDBM50200978(CHEMBL3956037 | US10087187, Compound 58)
Affinity DataKd:  20nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

LigandPNGBDBM50200978(CHEMBL3956037 | US10087187, Compound 58)
Affinity DataKd:  1.23E+4nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50200978(CHEMBL3956037 | US10087187, Compound 58)
Affinity DataKd:  2.14E+4nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent