BDBM50200895 (S)-benzyl 8-(hydroxyamino)-1,8-dioxo-1-(quinolin-8-ylamino)octan-2-ylcarbamate::CHEMBL221955

SMILES ONC(=O)CCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1cccc2cccnc12

InChI Key InChIKey=UEGKDJGASMFKBQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50200895   

TargetHistone deacetylase 1(Human)
Kyushu Institute of Technology

LigandPNGBDBM50200895((S)-benzyl 8-(hydroxyamino)-1,8-dioxo-1-(quinolin-...)
Affinity DataIC50: 10nMAssay Description:For the enzyme assay, 10 µL of the enzyme fraction was added to 1 µL of fluorescent substrate (2 mM Ac-KGLGK(Ac)-MCA) and 9 µL of histone deacetylase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Kyushu Institute of Technology

LigandPNGBDBM50200895((S)-benzyl 8-(hydroxyamino)-1,8-dioxo-1-(quinolin-...)
Affinity DataIC50: 11nMAssay Description:For the enzyme assay, 10 µL of the enzyme fraction was added to 1 µL of fluorescent substrate (2 mM Ac-KGLGK(Ac)-MCA) and 9 µL of histone deacetylase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details Article
PubMed
TargetHistone deacetylase 6(Mouse)
Kyushu Institute of Technology

LigandPNGBDBM50200895((S)-benzyl 8-(hydroxyamino)-1,8-dioxo-1-(quinolin-...)
Affinity DataIC50: 45nMAssay Description:For the enzyme assay, 10 µL of the enzyme fraction was added to 1 µL of fluorescent substrate (2 mM Ac-KGLGK(Ac)-MCA) and 9 µL of histone deacetylase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Kyushu Institute of Technology

LigandPNGBDBM50200895((S)-benzyl 8-(hydroxyamino)-1,8-dioxo-1-(quinolin-...)
Affinity DataIC50: 14.5nMAssay Description:Inhibition of human HDAC 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed