BDBM50200540 CHEMBL3972619

SMILES c1cc(ccc1CNc2cc(cc3c2cn[nH]3)Br)O

InChI Key InChIKey=YLKYPFSLPHIKQR-UHFFFAOYSA-N

Data  2 KI  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50200540   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50200540(CHEMBL3972619)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of recombinant human N-terminus IDO1 expressed in Escherichia coli assessed as N-formylkynurenine formation using L-tryptophan as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIndoleamine 2,3-dioxygenase 1(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50200540(CHEMBL3972619)
Affinity DataIC50: 5.64E+3nMAssay Description:Inhibition of human IDO1 by Cornhish-Bowden methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTryptophan 2,3-dioxygenase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50200540(CHEMBL3972619)
Affinity DataIC50: 2.04E+3nMAssay Description:Inhibition of human TDO by Cornhish-Bowden methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50200540(CHEMBL3972619)
Affinity DataIC50: 5.64E+3nMAssay Description:Inhibition of human IDO1 (12 to 403 aa) expressed in Escherichia coli Transetta (DE3) by nanodrop 2000c spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTryptophan 2,3-dioxygenase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50200540(CHEMBL3972619)
Affinity DataIC50: 1.85E+3nMAssay Description:Inhibition of human TDO (19 to 388 aa) expressed in Escherichia coli Transetta (DE3) by nanodrop 2000c spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50200540(CHEMBL3972619)
Affinity DataKi:  390nMAssay Description:Binding affinity to human TDO assessed as inhibition constant by Cornhish-Bowden methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50200540(CHEMBL3972619)
Affinity DataKi:  2.98E+3nMAssay Description:Binding affinity to human IDO1 assessed as inhibition constant by Cornhish-Bowden methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)