BDBM50200392 CHEMBL383899::Cyclopropanecarboxylic acid-(3-(4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino)-phenyl)-amide::N-3-4-3-trifluoromethyl)phenylamino)pyrimidin-2-ylamino)phenyl)cyclopropanecarboxamide::N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE

SMILES c1cc(cc(c1)Nc2ccnc(n2)Nc3cccc(c3)NC(=O)C4CC4)C(F)(F)F

InChI Key InChIKey=RDTDWGQDFJPTPD-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50200392   

TargetAurora kinase A(Human)
Activesight

Curated by ChEMBL
LigandPNGBDBM50200392(N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMID...)
Affinity DataIC50: 42nMAssay Description:Inhibition of Aurora-AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Activesight

Curated by ChEMBL
LigandPNGBDBM50200392(N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMID...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Human)
Weill Cornell Medical College

Curated by ChEMBL
LigandPNGBDBM50200392(N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMID...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Activesight

Curated by ChEMBL
LigandPNGBDBM50200392(N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMID...)
Affinity DataIC50: 42nMAssay Description:Inhibition of Aurora kinase AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Lck(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50200392(N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMID...)
Affinity DataIC50: 131nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50200392(N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMID...)
Affinity DataIC50: 386nMAssay Description:Inhibition of BmxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50200392(N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMID...)
Affinity DataIC50: 591nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50200392(N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMID...)
Affinity DataIC50: 887nMAssay Description:Inhibition of SykMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Activesight

Curated by ChEMBL
LigandPNGBDBM50200392(N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMID...)
Affinity DataIC50: 42nMAssay Description:Inhibition of Aurora A kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)